FIB-SEM 3D rendering of myelinated axons in the mouse hippocampus
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3D FIB-SEM imaging confirms sub cellular structures in mouse cortical neurons. Researcher Ruixuan and Srigokul et al. [science.sciencemag.org/content/363/6424/eaau8302] combined expansion microscopy and lattice light-sheet microscopy to image the nanoscale spatial relationships between proteins across the thickness of the mouse cortex or the entire Drosophila brain. These included synaptic proteins at dendritic spines, myelination along axons, and presynaptic densities at dopaminergic neurons in every fly brain region.
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